Medication Safety Information
Last updated: September 17, 2026
The information below provides important safety information regarding compounded medications that may be prescribed by an independent licensed healthcare provider through the NativeMed platform.
NativeMed is not a pharmacy and does not manufacture or compound medications. Prescription medications are prescribed only when an independent licensed healthcare provider determines that treatment is medically appropriate for an individual patient. Prescriptions are filled and dispensed by independent, appropriately licensed compounding pharmacies.
Compounded medications are not FDA-approved. The FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed.
The information below is for general educational and safety purposes and does not replace the instructions provided by your healthcare provider, dispensing pharmacy, or medication labeling. Always follow the specific directions provided with your prescription.
Compounded Semaglutide
Important Information
Compounded semaglutide is a prescription medication that may be prescribed by a licensed healthcare provider when the provider determines that a compounded medication is appropriate for an individual patient's medical needs.
Compounded semaglutide is not FDA-approved and has not been reviewed by the FDA for safety, effectiveness, or quality.
Compounded medications may differ in formulation, concentration, packaging, inactive ingredients, and dosing instructions depending on the dispensing pharmacy and the patient's prescription.
Use your medication only as specifically prescribed and dispensed for you.
Who Should Not Use Semaglutide?
Tell your healthcare provider about all medical conditions before beginning treatment.
You should not use semaglutide if:
You or a family member have a history of medullary thyroid carcinoma (MTC).
You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
You have had a serious allergic reaction to semaglutide or any ingredient in your prescribed formulation.
Tell your healthcare provider if you:
Have or have had problems with your pancreas or kidneys.
Have a history of diabetic retinopathy.
Have severe stomach or digestive problems.
Have or have had gallbladder problems.
Have diabetes and use insulin or other medications that can lower blood sugar.
Have a history of depression, suicidal thoughts, or significant changes in mood or behavior.
Are pregnant, planning to become pregnant, or breastfeeding.
Take any prescription medications, over-the-counter medications, vitamins, or supplements.
Important Safety Warning
Semaglutide has caused thyroid C-cell tumors in rodents. It is not known whether semaglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans.
Tell your healthcare provider immediately if you develop a lump or swelling in your neck, persistent hoarseness, difficulty swallowing, or shortness of breath.
Possible Side Effects
Serious side effects may include:
Pancreatitis
Stop using the medication and contact your healthcare provider immediately if you experience severe or persistent abdominal pain, particularly if the pain radiates to your back, with or without vomiting.
Gallbladder problems
Symptoms may include pain in the upper abdomen, fever, yellowing of the skin or eyes, or clay-colored stools.
Low blood sugar (hypoglycemia)
The risk may be greater when semaglutide is used with insulin or certain other diabetes medications. Symptoms can include sweating, shakiness, dizziness, confusion, weakness, headache, blurred vision, slurred speech, anxiety, hunger, or rapid heartbeat.
Kidney problems
Nausea, vomiting, and diarrhea may cause dehydration, which can worsen kidney problems. Drink fluids as directed and contact your healthcare provider if gastrointestinal symptoms are severe or persistent.
Serious allergic reactions
Seek immediate medical attention for swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; fainting; or a very rapid heartbeat.
Changes in vision
Tell your healthcare provider if you experience changes in vision, particularly if you have diabetes or a history of diabetic retinopathy.
Severe gastrointestinal problems
Semaglutide can cause gastrointestinal side effects that may sometimes be severe. Contact your healthcare provider if symptoms are persistent or significant.
Common Side Effects
Common side effects associated with semaglutide may include:
Nausea
Vomiting
Diarrhea
Constipation
Abdominal pain or discomfort
Indigestion or upset stomach
Side effects may be more noticeable when beginning treatment or when your dose changes.
Contact your healthcare provider if side effects are severe, persistent, or concerning.
Pregnancy and Breastfeeding
Tell your healthcare provider if you are pregnant, believe you may be pregnant, are planning to become pregnant, or are breastfeeding.
Semaglutide should not be used during pregnancy. Discuss appropriate discontinuation timing with your healthcare provider if you plan to become pregnant.
How to Use Your Medication
Follow the exact instructions provided by your healthcare provider and dispensing pharmacy.
If prescribed an injectable compounded semaglutide product:
Use only the dose prescribed specifically for you.
Carefully review the concentration listed on your medication label.
Follow the pharmacy's instructions for measuring your dose.
Use the syringe or administration supplies provided or recommended for your prescription.
Do not change your dose or dosing schedule unless instructed by your healthcare provider.
Rotate injection sites as instructed.
Do not share medication or injection supplies with another person.
Compounded products can be available in different concentrations. The number of syringe "units" required for one patient's prescription may therefore be different from another patient's prescription.
Never determine your dose by comparing your syringe units with another patient's dose or instructions.
If you are unsure how much medication to administer, do not inject the medication until you have confirmed the correct dose with your healthcare provider or dispensing pharmacy.
If You Take Too Much
If you believe you administered more medication than prescribed, contact your healthcare provider promptly.
You may also contact Poison Control at 1-800-222-1222.
For severe or life-threatening symptoms, call 911 or seek emergency medical attention.
Compounded Tirzepatide
Important Information
Compounded tirzepatide is a prescription medication that may be prescribed by a licensed healthcare provider when the provider determines that a compounded medication is appropriate for an individual patient's medical needs.
Compounded tirzepatide is not FDA-approved and has not been reviewed by the FDA for safety, effectiveness, or quality.
Compounded medications may differ in formulation, concentration, packaging, inactive ingredients, and dosing instructions depending on the dispensing pharmacy and the patient's prescription.
Use your medication only as specifically prescribed and dispensed for you.
Who Should Not Use Tirzepatide?
Tell your healthcare provider about all medical conditions before beginning treatment.
You should not use tirzepatide if:
You or a family member have a history of medullary thyroid carcinoma (MTC).
You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
You have had a serious allergic reaction to tirzepatide or any ingredient in your prescribed formulation.
Tell your healthcare provider if you:
Have or have had problems with your pancreas or kidneys.
Have severe stomach or digestive problems.
Have or have had gallbladder problems.
Have diabetes or diabetic retinopathy.
Use insulin or other medications that can lower blood sugar.
Have a history of depression, suicidal thoughts, or significant changes in mood or behavior.
Are pregnant, planning to become pregnant, or breastfeeding.
Take oral medications, including oral hormonal contraceptives.
Take any prescription medications, over-the-counter medications, vitamins, or supplements.
Important Safety Warning
Tirzepatide has caused thyroid C-cell tumors in rodents. It is not known whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans.
Tell your healthcare provider immediately if you develop a lump or swelling in your neck, persistent hoarseness, difficulty swallowing, or shortness of breath.
Possible Serious Side Effects
Serious side effects may include:
Pancreatitis
Stop using the medication and contact your healthcare provider immediately if you experience severe or persistent abdominal pain, particularly if the pain radiates to your back, with or without vomiting.
Gallbladder problems
Symptoms may include pain in the upper abdomen, fever, yellowing of the skin or eyes, or clay-colored stools.
Low blood sugar (hypoglycemia)
The risk may be greater when tirzepatide is used with insulin or certain other diabetes medications.
Kidney problems
Vomiting, nausea, and diarrhea can cause dehydration and may worsen kidney problems.
Serious allergic reactions
Seek immediate medical attention for swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; fainting; or a very rapid heartbeat.
Severe gastrointestinal problems
Tirzepatide may cause gastrointestinal side effects that can sometimes be severe. Contact your healthcare provider if symptoms are persistent or significant.
Changes in vision
Tell your healthcare provider if you experience changes in vision, particularly if you have diabetes or diabetic retinopathy.
Common Side Effects
Common side effects associated with tirzepatide may include:
Nausea
Diarrhea
Vomiting
Constipation
Abdominal pain or discomfort
Indigestion
Decreased appetite
Side effects may be more noticeable when beginning treatment or when your dose changes.
Contact your healthcare provider if side effects are severe, persistent, or concerning.
Pregnancy, Breastfeeding, and Birth Control
Tell your healthcare provider if you are pregnant, believe you may be pregnant, are planning to become pregnant, or are breastfeeding.
Tirzepatide should not be used during pregnancy.
Tirzepatide may affect the absorption of oral medications because it delays gastric emptying. This may affect the effectiveness of oral hormonal contraceptives, particularly after starting treatment or increasing the dose.
Discuss contraception and your other medications with your healthcare provider.
How to Use Your Medication
Follow the exact instructions provided by your healthcare provider and dispensing pharmacy.
If prescribed an injectable compounded tirzepatide product:
Use only the dose prescribed specifically for you.
Carefully review the concentration listed on your medication label.
Follow the pharmacy's instructions for measuring your dose.
Use the syringe or administration supplies provided or recommended for your prescription.
Do not change your dose or dosing schedule unless instructed by your healthcare provider.
Rotate injection sites as instructed.
Do not share medication or injection supplies with another person.
Compounded products can be available in different concentrations. The number of syringe "units" required for one patient's prescription may therefore be different from another patient's prescription.
Never determine your dose by comparing your syringe units with another patient's dose or instructions.
If you are unsure how much medication to administer, do not inject the medication until you have confirmed the correct dose with your healthcare provider or dispensing pharmacy.
If You Take Too Much
If you believe you administered more medication than prescribed, contact your healthcare provider promptly.
You may also contact Poison Control at 1-800-222-1222.
For severe or life-threatening symptoms, call 911 or seek emergency medical attention.
Important Information About Compounded Medications
Compounded tirzepatide is a prescription medication that may be prescribed by a licensed healthcare provider when the provider determines that a compounded medication is appropriate for an individual patient's medical needs.
Compounded tirzepatide is not FDA-approved and has not been reviewed by the FDA for safety, effectiveness, or quality.
Compounded medications may differ in formulation, concentration, packaging, inactive ingredients, and dosing instructions depending on the dispensing pharmacy and the patient's prescription.
Use your medication only as specifically prescribed and dispensed for you.
Who Should Not Use Tirzepatide?
Tell your healthcare provider about all medical conditions before beginning treatment.
You should not use tirzepatide if:
You or a family member have a history of medullary thyroid carcinoma (MTC).
You have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
You have had a serious allergic reaction to tirzepatide or any ingredient in your prescribed formulation.
Tell your healthcare provider if you:
Have or have had problems with your pancreas or kidneys.
Have severe stomach or digestive problems.
Have or have had gallbladder problems.
Have diabetes or diabetic retinopathy.
Use insulin or other medications that can lower blood sugar.
Have a history of depression, suicidal thoughts, or significant changes in mood or behavior.
Are pregnant, planning to become pregnant, or breastfeeding.
Take oral medications, including oral hormonal contraceptives.
Take any prescription medications, over-the-counter medications, vitamins, or supplements.
Important Safety Warning
Tirzepatide has caused thyroid C-cell tumors in rodents. It is not known whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans.
Tell your healthcare provider immediately if you develop a lump or swelling in your neck, persistent hoarseness, difficulty swallowing, or shortness of breath.
Possible Serious Side Effects
Serious side effects may include:
Pancreatitis
Stop using the medication and contact your healthcare provider immediately if you experience severe or persistent abdominal pain, particularly if the pain radiates to your back, with or without vomiting.
Gallbladder problems
Symptoms may include pain in the upper abdomen, fever, yellowing of the skin or eyes, or clay-colored stools.
Low blood sugar (hypoglycemia)
The risk may be greater when tirzepatide is used with insulin or certain other diabetes medications.
Kidney problems
Vomiting, nausea, and diarrhea can cause dehydration and may worsen kidney problems.
Serious allergic reactions
Seek immediate medical attention for swelling of the face, lips, tongue, or throat; difficulty breathing or swallowing; severe rash or itching; fainting; or a very rapid heartbeat.
Severe gastrointestinal problems
Tirzepatide may cause gastrointestinal side effects that can sometimes be severe. Contact your healthcare provider if symptoms are persistent or significant.
Changes in vision
Tell your healthcare provider if you experience changes in vision, particularly if you have diabetes or diabetic retinopathy.
Common Side Effects
Common side effects associated with tirzepatide may include:
Nausea
Diarrhea
Vomiting
Constipation
Abdominal pain or discomfort
Indigestion
Decreased appetite
Side effects may be more noticeable when beginning treatment or when your dose changes.
Contact your healthcare provider if side effects are severe, persistent, or concerning.
Pregnancy, Breastfeeding, and Birth Control
Tell your healthcare provider if you are pregnant, believe you may be pregnant, are planning to become pregnant, or are breastfeeding.
Tirzepatide should not be used during pregnancy.
Tirzepatide may affect the absorption of oral medications because it delays gastric emptying. This may affect the effectiveness of oral hormonal contraceptives, particularly after starting treatment or increasing the dose.
Discuss contraception and your other medications with your healthcare provider.
How to Use Your Medication
Follow the exact instructions provided by your healthcare provider and dispensing pharmacy.
If prescribed an injectable compounded tirzepatide product:
Use only the dose prescribed specifically for you.
Carefully review the concentration listed on your medication label.
Follow the pharmacy's instructions for measuring your dose.
Use the syringe or administration supplies provided or recommended for your prescription.
Do not change your dose or dosing schedule unless instructed by your healthcare provider.
Rotate injection sites as instructed.
Do not share medication or injection supplies with another person.
Compounded products can be available in different concentrations. The number of syringe "units" required for one patient's prescription may therefore be different from another patient's prescription.
Never determine your dose by comparing your syringe units with another patient's dose or instructions.
If you are unsure how much medication to administer, do not inject the medication until you have confirmed the correct dose with your healthcare provider or dispensing pharmacy.
If You Take Too Much
If you believe you administered more medication than prescribed, contact your healthcare provider promptly.
You may also contact Poison Control at 1-800-222-1222.
For severe or life-threatening symptoms, call 911 or seek emergency medical attention.
Important Information About Compounded Medications
Compounded medications are prepared for individual patients pursuant to prescriptions when appropriate under applicable law.
Compounded medications are not FDA-approved. FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed.
A compounded medication should not be considered a generic version of an FDA-approved medication.
The appearance, concentration, formulation, packaging, instructions, and inactive ingredients of a compounded medication may vary depending on the dispensing pharmacy and the patient's individual prescription.
Your healthcare provider determines whether a particular treatment is medically appropriate for you. A prescription is not guaranteed by completing a NativeMed intake or medical assessment.
NativeMed does not manufacture or compound prescription medications.
Medication and Dosing Safety
Always review the label and instructions included with your medication before administering a dose.
Because compounded injectable medications may be dispensed in different concentrations, it is particularly important to understand the relationship between the prescribed dose, medication concentration, injection volume, and syringe markings.
Do not:
Increase your dose without instructions from your healthcare provider.
Take medication more frequently than prescribed.
Accelerate your dose escalation schedule.
Use another patient's dosing instructions.
Use a different syringe size or type unless instructed to do so.
Use medication that was prescribed for another person.
If anything about your prescription, concentration, syringe, or dosing instructions is unclear, contact your healthcare provider or dispensing pharmacy before administering the medication.
When to Seek Medical Attention
Contact your healthcare provider promptly if you develop new, worsening, persistent, or concerning symptoms during treatment.
Seek emergency medical attention or call 911 for symptoms that may represent a medical emergency, including difficulty breathing, severe allergic reaction, loss of consciousness, or other severe or life-threatening symptoms.
Reporting Side Effects
Patients should report side effects and medication concerns to their healthcare provider and, when appropriate, the dispensing pharmacy.
To report suspected severe side effects or adverse reactions to compounded trizepatide, contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. In case of emergencies, please call 911 or go to the nearest emergency room.
Questions About Your Medication
If you have questions about:
Your prescribed dose
Your medication concentration
How to measure your dose
Injection technique
Storage
Missed doses
Side effects
Medication interactions
Changes to your treatment
contact your healthcare provider or the pharmacy identified on your prescription label before making changes to your treatment.
Do not change your medication dose or treatment schedule without instructions from your healthcare provider.
Medical Disclaimer
This page provides general safety information and is not a substitute for professional medical advice, diagnosis, treatment, the medication labeling supplied by your dispensing pharmacy, or instructions from your healthcare provider.
Individual treatment decisions, including whether to prescribe a medication and the appropriate dose and dosing schedule, are made by licensed healthcare providers based on each patient's individual medical circumstances.